HLAMatchmaker is a structurally based computer algorithm to determine HLA matching at the epitope level. It focuses on epitopes recognized by HLA antibodies and the determination of epitope-based mismatch acceptability for sensitized patients considered for organ transplantation or in need of compatible platelet transfusions. It also explores the application of HLA mismatch permissibility at the epitope level to prevent allosensitization.

This website has several downloadable Excel-based HLAMatchmaker programs for epitope matching and antibody analysis; they use eplet notations and antibody-verified epitopes recorded in the International HLA Epitope Registry website www.epregistry.com.br

As of June 2016, there are Version 02 updates that include recently antibody-verified epitopes and incorporate additional analysis features. The Education section has now also “HLA Epitopia maps” that can be used as navigational tools in searches for new epitopes recognized by informative antibodies.

More than 150 HLA epitope-related publications can be accessed and the educational component has downloadable PowerPoint presentations and tutorials how to use HLAMatchmaker programs.

All files can be downloaded from this website free of charge.

Access to these files requires you to connect via a registered google account (not necessarily a gmail address).

Website Disclaimer

By using this website you agree that its contents are used only for research purposes and not for making clinical decisions regarding patient care and donor selection. Whereas this website attempts to provide high-quality information it does not offer any guarantee about its accuracy. We welcome your feedback about any component of this website.

To be able to download any of the actual HLAMatchmaker files, you must be authenticated via google. Please connect using google credentials, or create them.

For inquiries please contact:
Rene J Duquesnoy, Ph.D.
Professor Emeritus of Pathology
University of Pittsburgh Medical Center